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Review Article
Current health issues in Korean adolescents
Chang Ho Hong
Clin Exp Pediatr. 2011;54(10):395-400.   Published online October 31, 2011

During the adolescent period, they experience rapid physical, emotional, cognitive developments while they establish their lifestyle and habitual routines that strongly influence adult health and life. Recent rapid economic growth in Korea, and the earlier onset of physical, sexual, and psychological maturation of adolescents, has resulted in changes in the health status of adolescents from many years ago. Risk-taking behaviors...

Case Report
A Case of FGFR2 Exon Ⅲc Mutation in Crouzon Syndrome
Seon Chan Bae, Eun Ha Lee, Moon Sung Park, Si Houn Hah, Chang Ho Hong
Clin Exp Pediatr. 1998;41(12):1717-1721.   Published online December 15, 1998
Crouzon syndrome, an autosomal dominant disorder, has characteristic features of craniosynostosis, hypertelorism, exophthalmos, maxillary hypoplasia and relative mandibular prognathism. Mutations of fibroblast growth factor receptor 2(FGFR2) gene are associated with craniosynostotic conditions, such as Crouzon syndrome, Jackson-Weiss syndrome, Pfeiffer syndrome, Apert syndrome and Beare-Stevenson cutis gyrata. We found one child with common morphological features of Crouzon syndrome. Interestingly, she...
Meckel-Gruber syndrome
Jung Seo Park, Ji Yoen Lee, Sun Chan Bae, Moon Sung Park, Jung Seon Kim, Si Houn Hahn, Chang Ho Hong
Clin Exp Pediatr. 1998;41(6):856-860.   Published online June 15, 1998
Meckel-Gruber syndrome is a multiple malformation syndrome featuring occipital meningoencephalocele, multicystic dysplasia of kidney, cystic and fibrotic change of liver, polydactyly, and other characteristics inherited by the autosomal recessive trait. We exprienced a case of Meckel-Gruber syndrome in a newborn male diagnosed clinically and confirmed pathologically. Abnormalities of the fetus were found prenataly by ultrasonogram, and subsequently the baby was...
Original Article
Pollen Allergy in Children(Ⅱ) : The Significance of Tree Pollen As a Causative Allergen in Children with Allergic Diseases
Soo-Young Lee, Jeong-Soe Park, Ki-Sun Lee, Chang Ho Hong
Clin Exp Pediatr. 1998;41(6):799-807.   Published online June 15, 1998
Purpose : The positive rates of allergy skin test of pollens are relatively higher in children in Suwon compared to other areas in Korea. To evaluate the significance of tree pollen as a causative allergen, we undertook this study. Methods : In 252 children with asthma, scratch tests were done with 72 extracts, including 9 tree pollen. Antigen specific serum IgE antibodies were measured...
Analysis of Urinary Mass Screening for Elemantary, Junior and High School Children Over a 8-year Period in Seoul
Chong Guk Lee, Dong Whan Lee, Sae Won Yang, Sung Ho Cha, Chang Ho Hong, Yong Mook Choi, Hyun Soon Lee, Sung Jae Seo
Clin Exp Pediatr. 1997;40(10):1347-1359.   Published online October 15, 1997
Purpose : The urinary mass screening program for the detection of proteinuria had been performed for a school age population in the city of Seoul since 1981. However, systematic evaluation for this program had never been done. We, therefore, designed a systematic evaluation in corporation with the Seoul School Health Center for students with proteinuria identified in the mass screening to determine the prevalence...
Case Report
Acute Tyrosinemia Type 1 in a 5 Month Old Korean Boy
Si Houn Hahn, Ki Soo Pai, Ki Bum Lee, Kwang Hwa Park, Ok Hwa Kim, Chang Ho Hong, Baek Lin Eun, Seiji Yamaguchi
Clin Exp Pediatr. 1996;39(6):866-872.   Published online June 15, 1996
Tyrosinemia type 1 is an autosomal recessive disorder caused by deficiency of the enzyme fumarylacetoacetate hydrolase(FAH). The disease is characterized by hepatic dysfuntion, hepatocellular carcinomas, renal tubular dysfunction, rickets, and neurologic crises. Two forms of the disease, acute and chronic, are thought to be from the residual enzyme activity in the liver. The diagnosis of the tyrosinemia type 1 is suggested by...
Original Article
Upper Limit of Normal Value for Antistreptolysin O Titer of Healthy Children in Seoul
Sung Ho Cha, Yong Mook Choi, Sei Won Yang, Dong Hwan Lee, Chong Guk Lee, Chang Ho Hong
Clin Exp Pediatr. 1995;38(8):1061-1068.   Published online August 15, 1995
Purpose : We have found somewhat high titer of antistreptolysin O (ASO) accidentally when we had delineated normal carrier rate of beta hemolytic streptococci in rural area of Kangwon Province in 1991(1). We would like to know upper limit of normal value of ASO and re-valuated results which might be changed with different geographic areas, age, and prevalent rate...
Statistical Observation for the Pediatric Patients in ICU
Ki Hun Eum, Chang Ho Hong, Young Mo Sohn, Chul Lee, Pyung Kil Kim
Clin Exp Pediatr. 1992;35(6):762-768.   Published online June 15, 1992
A statistical study was performed on 221 ICU cared pediatric patients who were admitted to the department of pediatrics, Yonsei university college of medicine, Seoul, Korea from Apr. 1983 to Mar. 1991. The results were as follows : 1) Total number of subject were 221, it was 7.5% of total ICU patients and 1.3% fo total admitted pediatric patients. The male to...
Physical Growth According to Sexual Maturation of Korean Adolescents
Hwan Gyu Park, Chang Ho Hong, Duk Hi Kim
Clin Exp Pediatr. 1994;37(9):1187-1195.   Published online September 15, 1991
Adolescence is the period in which physical, mental and social maturation occurs and it is an important transit stage, changing from childhood to adulthood. This is a period in which important changes occur physically such as rapid growth in height and weight gain but significant differences in growth may occur for the same age. Therfore, the degree of sexual maturation...
A case of Gaucher's Disease Diagnosed by beta-Glucosidase Enzyme Deficiency.
Hwan Gyn Park, Yil Sub Lee, Chang Hyun Yang, Chang Ho Hong, Sung Kyu Lee, Kyung Soon Song, Hyeon Joo Jeong
Clin Exp Pediatr. 1990;33(4):514-521.   Published online April 30, 1990
We experienced a case of adult type Gaucher’s disease in a 2 year 9 month old female. The patient had hepatosplenomegaly with anemia and characteristic Gaucher cells in bone marrow aspiration and biopsy of liver and spleen. Diagnosis was confirmed by demonstration of β-glucosidase enzyme deficiency in circulating leukocytes. Partial splenectomy was followed by improvement of anemia and thrombocytopenia. A brief review of literature was done.
Unusual Forms of Pulmonary and Extrapulmonary Manifestations of Mycoplasmal Pneumonia.
Young Soo Lee, Chang Ho Hong, Chul Lee, Sung Gyu Lee
Clin Exp Pediatr. 1989;32(8):1064-1073.   Published online August 31, 1989
A clinical study was performed on 145 patients admitted to the Departement of Pediatrics, Yong Dong Severance Hospital between July, 1984 and June, 1987 with the diagnosis of Mycoplasmal pneumonia. This diagnosis was done when chest X-ray or auscultation of the chest showed signs of pneumonia. Patients with cold agglutinin titrations of 1:64 or titrations with four fold increase during follow up had Indirect...
A Comparative clinical study of Intussusception with Barium or Surgical Reduction.
Hyeon Soo Lee, Chang Ho Hong, Ki Sub Chung, Sung Gyu Lee, Ki Gun Oh, Sung Guk Sohn
Clin Exp Pediatr. 1988;31(9):1146-1152.   Published online September 30, 1988
A chinical study was performed on 294 cases of intussusception in infants and children, who were admitted to the Department of Pediatrics, Yong Dong Severance Hospital from January, 1983 to December, 1986. 240 cases were treated by barium reduction, were analysed clinically and were compared with 54 cases treated surgrally. The results were as followed: 1) As for the peak incidence of intussusception, 30.4% of...
Abdominal Ultrasonographic Findings in Patients with Kawasaki Disease.
Ho Taek Kim, Chang Ho Hong, Chul Lee, Sung Kyu Lee, Pyung Kil Kim, Ki Kun Oh
Clin Exp Pediatr. 1988;31(3):348-354.   Published online March 31, 1988
Kawasaki disease, first reported in Korea in 1973, is now one of the disease commonly encountered in pediatric age group. It presents systemic symptoms including abdominal ones such as pain, nausea and vomiting, etc. There have been several case reports of hydrops of the gallbladder occuring concurrently with Kawasaki disease, and the abdominal symptoms of the disease are known to correlate with hydrops of...
Factors Influencing the Prognosis of Reye Syndrome.
Chang Ho Hong, Heung Dong Kim, Pyung Kil Kim
Clin Exp Pediatr. 1987;30(11):1252-1258.   Published online November 30, 1987
While the etiology of Reye syndrome is still unknown, wide variations in both the clinical spectrum and the therapeutic outcome of patients have been noted. We reviewed the cases of 42 Reye syndrome patients who were admitted to Young Dong Severance Hospital during the period from April, 1983 to July, 1986 and analyzed factors influencing the prognosis of Reye syndrome. The patients were divided...
The Effect of Hepatitis B Vaccination on Newborns of Hepatitis B Carrier Mothers.
Ho Taek Kom, Pyung Kil Kim, Chang Ho Hong, Chul Lee
Clin Exp Pediatr. 1987;30(11):1228-1235.   Published online November 30, 1987
The transmission of hepatitis B virus (HBV) from carrier mothers to their infants is a serious problem in many countries and the transmission rate is reported to be as high as 60%. The best preventive method of perinatal transmission is hepatitis B immune globulin (HBIG) which confers a passive immunity and HB vaccine which confers an active immunity. However, the exact dosage and the...
Chronic Hepatitis B in Children.
Don Gyu Yang, Jong Kyun Lee, Pyung Kil Kim, Chang Ho Hong, Chul Lee
Clin Exp Pediatr. 1987;30(10):1115-1123.   Published online October 31, 1987
We reviewed 19 cases of chronic hepatitis B confirmed by liver biopsy during the 3 years and 5months from March 1983 to July 1986 at Young Dong Severance Hospital. The following results were obtained: 1) There were 16 boys and 3 girls with ages ranging from 7 months to 14 years old (mean+S.D.; 6.5 ±0.9 years). 2) There were 2 cases (10.5%) of chronic persistent...
A Case of Cloverleaf Skull; Kleeblattschael Syndrome.
Chang Hyon Yang, Kyu Earn Kim, Chang Ho Hong, Young Mo Sohn, Don Gyu Yang, Kee Keun Oh
Clin Exp Pediatr. 1987;30(4):456-460.   Published online April 30, 1987
A case of Cloverleaf skull; Kleeblattschadel syndrome in a 70-day old male infant with facial deformity since birth was seen. The diagnosis was made on the basis of typical morphologic clinical features an radiologic findings. A brief review of the related literature was given.
Importance of radiographic study of urinary tract infection in children.
Chang Ho Hong, Kyu Earn Kim, Pyung Kil Kim
Clin Exp Pediatr. 1982;25(4):334-339.   Published online April 30, 1982
In urinary tract infection of childhood, the intravenous pyelogram is helpful in identifying gross malformations of urinary tract and appraising gross renal function. The voiding cystourethrogram evaluates configuration and function of the lower urinary tract and is most useful for delineating the presence and severity of vesicoureteral reflux. The intravenous pyelogram is suggested for every male patients with one documented...
Selective Protein Index and Response to Treatment in the Childhood Nephrotic Syndrome.
Chang Ho Hong, Chul Lee, Pyung Kill Kim, Duk Jin Yun
Clin Exp Pediatr. 1981;24(7):645-651.   Published online July 15, 1981
In a group of 59 children with nephrotic syndrome who had been admitted to Severance Ho-spital, during the period of 2 years from July of 1978 till June of 1980, the histological picture seen on renal biopsy, the selective protein index, and the response to the steroid therapy were studied. The degree of selective protein index is not related to...
Liver Abscess in Childhood.
Back Keun Lim, Hee Seon AuK, Kwan Sub Chung, Chang Ho Hong, Jae Seung Lee
Clin Exp Pediatr. 1980;23(12):999-1007.   Published online December 31, 1980
We have presented an analysis of cases of liver abscess from the record of the Department of Pediatrics, Yonsei medical College, during the 10 year 8 months period from Jan. 1969 through Sept. 1979. The incidence of admission in pediatric was 0.05025%. There was male preponderance. The most frequently encountered symptoms and sings were fever and chill, anorexia, hepatomegale, pain...
Thyroid Disease in Childhood.
Duk Hi Kim, Chang Ho Hong, Kyung Suk Han, Dong Sik Jin
Clin Exp Pediatr. 1980;23(8):653-661.   Published online August 15, 1980
Diseases of the thyroid gland are manifested by either increase in gland size, alterations in hormonal secretion, or both. Changes in gland size and weight are associated with toxic or nontoxic goiter, adenomas, thyroiditis, or malignancies. Many reports can be found to study thyroid disease, but there is no report of thyroid disease in childhood. So the present studies have...
Congenital Hypothyroidism.
Duk Hi Kim, Chang Ho Hong, Baek Keum Lim, Jung Sang Oh, Jung Soo Kim
Clin Exp Pediatr. 1980;23(7):550-556.   Published online July 15, 1980
We made a clinical observation of 17 cases of congenital Hypothyroidism at the Pediatric department of Yonsei University hospital in Seoul, Korea during the period from January, 1969 to August, 1979. The results were as followings : 1) Male to female sex was about 1 : 1.1, and 6 cases (35%) of congenital hypothyroid-sm were diagnosed under 1 year old....
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